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Around 30% of GBM patients harbor p53 mutation. login e bupot In malignant tumors with wt-p53, the normal function of p53 is suppressed by Mouse double minute 2 homolog (MDM2) and Mouse double minute 4 homolog (MDM4). link login club388 Remarkably, like MDM2, EGFR amplification shows mutual exclusivity with TP53 mutation in GBM